fa Mathematical Modeling and Applications of OR Mathematical Modeling and Applications of OR پژوهشی Original <em>This paper presents a structure that empower designing supervisory groups to survey the estimation of real options in projects of enormous scale, incompletely standardized frameworks actualized a couple of times over the medium term. Specific options writing is done using a methodology of planning the design and making prior decisions regarding the arrangements of specific options, with a recreation-based value measure designed to be near-current construction rehearsals and to resolve financial problems in particular cases.</em><em> To study the case and demonstrate the actual application of this method, drug chain modeling at the tactical level was investigated. The physical and financial flow and their disturbance are simultaneously modulated. In order to complete the financial flow, financial ratios are also entered into the model. Problem uncertainty has been modeled using one of the most recent robust optimization approaches called Robust Possibilistic Programming (RPP) in combination with real options theory.</em> <em>The model was applied to a case study and its results were analyzed and validated by GAMS software. The results show that without violating the limitations of the problem, it shows appropriate decisions to deal with the problem.</em> Sustainable planning, drug supply chain, real options theory, robust possibilistic programming 19 42 http://iors.ir/journal/browse.php?a_code=A-10-1422-8&slc_lang=fa&sid=1 Aidin Azari Marhabi Aidin Azari Marhabi aidinak626@gmail.com 1111111111 1111111111 Yes Babol Noshirvani University of Technology دانشگاه صنعتی نوشیروانی Abdollah Arasteh عبدالله آراسته arasteh@nit.ac.ir 1111111111 1111111111 No Babol Noshirvani University of Technology دانشگاه صنعتی نوشیروانی Mohammad Mahdi Paydar محمد مهدی پایدار paydar@nit.ac.ir 1111111111 1111111111 No Babol Noshirvani University of Technology دانشگاه صنعتی نوشیروانی